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Research Breakthroughs

The three most important factors in real estate are location, location, location, and the same might be said for mutations in the gene MECP2, said researchers in a report in the journal Cell. In the study, the researchers relied on data from rare male patients with disruptions in MECP2 that showed that severity of symptoms could be influenced by the location of the gene mutation.

A snippet of genetic material called microRNA provides new insight into the control of the protein MeCP2, which causes disease when there is too much or too little of it in the brain, said researchers in a report in the journal Genes and Development. In this report, Dr. Zoghbi and her colleagues describe a microRNA known as miR-483-5p that plays an important role in regulating the levels of MeCP2 protein in the fetal brain during development.

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