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Yang He, Ph.D.

Dr. Yang He


1250 Moursund St.
Room N.0950.21
77030 TX
United States

Assistant Professor, Department of Pediatrics, Section of Neurology, Baylor College of Medicine.

Principal Investigator, the Jan and Dan Duncan Neurological Research Institute at Texas’s Children's Hospital.

Research Focus: Interplay between the central nervous system and systemic energy homeostasis, neural mechanisms underlying the development of obesity.

Obesity serves as a pivotal risk factor for diabetes, fatty liver diseases, cardiovascular disorders, and cancer. Obesity arises from an imbalance between energy intake and expenditure, with surplus energy being stored as triglycerides in adipose tissue. This intricate regulation of food intake and energy utilization is predominantly orchestrated by the central nervous system (CNS). My lab focuses on the neural mechanisms for the regulation of energy homeostasis. The ultimate goal is to identify druggable targets for combating obesity and metabolic disease.

Ongoing research projects:

1. Unraveling therapeutic interventions and mechanisms for obesity caused by HTR2C deficiency.
2. Investigating central mechanisms by which exercise-induced metabolite, Lac-Phe, suppresses feeding.
3. Exploring the interplay between olfaction and eating behavior.


Liu H*, He Y*, Bai J, Zhang C... & Xu Y†.  Hypothalamic Grb10 Suppresses Obesity by Enhancing Leptin Signaling.  Nature Metabolism, 2023. doi: 10.1038/s42255-022-00701-x. PMID: 36593271.

He Y*, Brouwers B*, Liu H*, LiuH, Lawler K,…. & Xu Y†, Farooqi S 2†. Human loss-of-function variants in the Serotonin 2C receptor associated with obesity and maladaptive behavior. Nature Medicine, 2022 doi: 10.1038/s41591-022-02106-5. PMID: 36536256.

Li VL*, He Y*, Contrepois K, Liu H, ... & Xu Y†, Jonathan Long†. An exercise-inducible metabolite that suppresses feeding and obesity. Nature, 2022.doi: 10.1038/s41586-022-04828-5.

He Y*, Liu H*, Yin N, et al. Barbadin potentiates long-term effects of lorcaserin on POMC neurons and weight loss. Journal of Neuroscience, 2021, 41(26): 5734-5746.

He Y*, Wei M*, Wu Y, Qin H, Li W, Ma X, Cheng J, et al. Amyloid β oligomers suppress excitatory transmitter release via presynaptic depletion of phosphatidylinositol-4, 5bisphosphate. Nature Communications 10, no. 1 (2019): 1193. PMID: 30867420.

* co-first author

View all publications by Dr. Yang He