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Research Breakthroughs

An exciting study from the laboratories of Drs. Mirjana Maletic-Savatic and Juan Manuel Encinas, published in Cell Stem Cell, sheds light on how neuronal activity affects rNSC division and thereby, generation of new neurons in adults. They demonstrated that excessive neuronal activity results in the loss of rNSCs and thereby, affects short-term as well as long-term generation of new neurons in adult hippocampus.

In a recent study published in Nature Cell Biology, NRI researcher, Andrea Ballabio’s team has shown how starvation and exercise triggers a novel lysosomal calcium signaling cascade leading to transcriptional activation of the autophagic/lysosomal pathway. They found that under normal feeding conditions, mTORC1 kinase present on the lysosomal surface phosphorylates transcription factor B (TFEB), rendering it inactive. This form of TFEB can bind to 14-3-3 proteins that allows it to remain sequestered in the cytoplasm.

An exciting study published in Neuron from the laboratory of Dr. Benjamin Deneen has identified a novel mechanism that regulates formation of OLs via Wnt signalosomes. More importantly, it has identified a promising Wnt regulator that is capable of stimulating remyelination in animal models of cerebral palsy and adult white matter injury.

A recent study published in PLoS Biology, by a research team led by Drs. Chao Tong and Hugo Bellen has identified a novel mechanism by which neurons regulate autophagy. Autophagy is an evolutionarily conserved and tightly regulated cellular quality control process. It is an essential function that occurs in most cells to remove damaged organelles or misfolded proteins.

Baylor College of Medicine faculty and fruit fly biologists at the NRI, Drs. Michael Wangler, Shinya Yamamoto and Hugo J Bellen have published an article this week titled, “Fruit flies in Biomedical Research“, in the journal Genetics that explores the value of fruit fly research in biomedical discoveries and the need for additional funding. This insightful article provides an excellent summary of some of the key contributions resulting from a century of using fruit flies for biomedical research.

While it is known that defects in mitochondrial transport or dynamics in neurons result in neurological or neurodegenerative diseases, it is not clear what the underlying causative steps are. For instance, while it was known that loss of mitochondrial fusion protein, Mitofusin 2 (Mfn2) causes Charcot Marie Tooth type 2A (CMT2A), a progressive and severe loss of motor neurons, the mechanism by which functional loss of Mfn2 result in neuropathy is not clear. A recent paper from Dr. Hugo Bellen’s lab provides a clue.

A pioneering study published this month in eLife by Dr. Yuri Dabaghian and his colleagues at the NRI and the University of California at San Francisco, suggests the existence of a simpler, yet elegant mechanism. They show that place cells ignore all extraneous geometric information and merely convey a “rough and ready” topological map of the environment. In other words, the hippocampal map consists merely of a sequence of spatial locations, analogous to a city's subway map.

This week, in Developmental Cell, Dr. Arenkiel and his team report a novel role for a small, soluble neuropeptide, Corticotrophin Release Hormone (CRH) in promoting synapse formation and circuit integration of neurons generated in the adult mouse brain. Traditionally, CRH has been studied as a hypothalamic stress hormone. However, it is now known that CRH is released by various neurons throughout the brain.

The three most important factors in real estate are location, location, location, and the same might be said for mutations in the gene MECP2, said researchers in a report in the journal Cell. In the study, the researchers relied on data from rare male patients with disruptions in MECP2 that showed that severity of symptoms could be influenced by the location of the gene mutation.

A snippet of genetic material called microRNA provides new insight into the control of the protein MeCP2, which causes disease when there is too much or too little of it in the brain, said researchers in a report in the journal Genes and Development. In this report, Dr. Zoghbi and her colleagues describe a microRNA known as miR-483-5p that plays an important role in regulating the levels of MeCP2 protein in the fetal brain during development.