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Research Breakthroughs

A collaborative study identifies a new neurodevelopmental syndrome due to the lysosomal dysfunction in the absence of OXR1.

Bellen lab discover that a Zika virus protein (NS4A) disrupts brain growth by hijacking the ANKLE2 and VRK1 -mediated neurogenesis pathway, which opens up the exciting possibility of developing VRK1 kinase inhibitors as therapeutic targets for microcephaly, particularly for congenital Zika syndrome.

A collaborative study from the Bellen lab finds mutations in IQSEC1 resposible for a new intellectual disability syndrome.

Researchers in Shulman and Liu labs show tau-mediated aggregates sequesters core components of the spliceosome complex leading to dgeneration and loss of neurons in the brains of Alzheimer's patients.

New study shows molecular profiling can predict the recurrence of meningiomas better than current histopathological calssifications.

A Cell paper published from the Zoghbi and Tanzi labs shows loss of ataxin-1 gene, which is known to cause the rare neurodegenerative disease called spinocerebellar ataxia type 1 (SCA1), function can increase the risk of Alzheimer’s disease in a mouse model of the condition.

Shulman et al. identify the mechanism by which mutations in CD2AP/cindr increases susceptibility to Alzheimer's disease.

UDN links WDR37 gene to a novel neurological syndrome.

Arenkiel lab has identified a novel basal forebrain circuit that controls feedling behaviors.

MOANA, a nonsurgical device capable of decoding neural activity in one person's visual cortex and recreating it another person's in one-twentieth of a second.

NRI researchers participate in an exciting DARPA-funded project.

Like finding a needle in a haystack, identifying genes that are involved in particular diseases can be an arduous and time consuming process. Looking to improve this process, a team led by researchers at Baylor College of Medicine has developed a new bioinformatics tool that analyzes CRISPR pooled screen data and identifies candidates for potentially relevant genes with greater sensitivity and accuracy than other existing methods. The new analytical web-based tool also is quicker and more user friendly as it does not require bioinformatics training to use it.

Some neuropsychiatric conditions may boil down to how well brain cells communicate with each other. This can be affected by a number of factors, including having too much or too little of proteins that function at the synapse – the point of communication between two brain cells. SHANK3 is one of these proteins. In their labs, Dr. Huda Zoghbi, Dr. Jimmy L. Holder Jr. and their colleagues have been extensively studying SHANK3, and they and other labs have discovered what is good, bad and hopeful about this protein.

A study from Dr. Hugo Bellen's lab shows how ubiquilin proteins regulate lysosomal function, which suggests potential therapies for amyolateral sclerosis and frontotemporal dementia.

A study from Dr. Marco Sardiello's lab finds development of tuberous sclerosis involves a second mTORC1-independent mechanism.

A collaborative study from the Bellen lab provides new insights into how dengue and Zika viruses cause disease reveal shared and virus-specific mechanisms.

A team of researchers at Baylor College of Medicine, the Texas Heart Institute and Texas Children’s Hospital has developed a powerful new approach to understand the formation of new neurons in the mammalian adult brain.

In a study published in Nature Neuroscience, a co-author, Dr. Jimmy L. Holder Jr., neurologist and director of the new SYNGAP1 Center of Excellence at Texas Children’s Hospital, investigator at the Jan and Dan Duncan Neurological Research Institute at Texas Children’s and assistant professor at Baylor College of Medicine, analyzed retrospective clinical data of SYNGAP1 patients from a registry maintained by Bridge the Gap – SYNGAP1 Education and Research Foundation.

A recent study from Dr. Marco Sardiello's lab shows defective lysosomal biogenesis as the underlying cause of Neuronal Ceroid Lipofuscinoses 8 (NCL8).

Researchers in Sardiello lab find Src regulates mTORC1, both of which are known to be hyperacive in cancer. This study offers the possibility to develop novel approaches to control cancer growth.

A study in the New England Journal of Medicine reports the Undiagnosed Diseases Network has identified 31 new syndromes and found diagnoses for 132 patients within two years of its inception.

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