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Research Breakthroughs

The Swann lab provides the first demonstration of a progressive increase in seizure duration along with a decline in learning and memory in the tetrodotoxin-induced model of infantile spasm.

The study reveals an extraordinary and an unprecedented mechanism for synaptic plasticity.

Researchers in the Bellen lab discover a new neurological disorder.

Jianyang Li and others in the Botas lab use an integrated functional genomics approach to find 50 new genes involved in Parkinson's disease.

The Bellen lab discovers that a spontaneous mutation in MTSS2 gene is the underlying cause of a new syndromic intellectual disability.

In a first-of-its-kind study, an international team of researchers report a comprehensive phenotypic and genotypic analysis of the largest cohort to date of patients with ANKLE2 gene variants, which were identified a few years ago as the cause of microcephaly (‘abnormally small head’) in infants.

The Duncan NRI team plan to use the Poly(A)Miner-Bulk tool to create a signature APA pattern for XDP, which can then be used to develop specific and effective diagnostic and treatment options for XDP patients. They are hopeful that if successful, this strategy can then be replicated for those with Parkinson’s disease and different forms of dystonia. 

The Xue lab and collaborators find a new class of light-gated channels that promise to pave the way for rapid and efficient optical neuronal silencing.  

A study by Bellen lab researchers is the first to associate neuronal activity to the levels of sphingolipids, a type of fat, in brain cells.

An exciting new study by Dr. Carlos Ballester-Rosado and others in the Swann lab finds an underlying cause and a potential new therapy for infantile spasms.

Dr. Chao and her team have discovered that patients with EBF3 gene variants affecting a critical region — zinc finger domain (ZNF) of the encoded transcription factor protein — suffer from a more severe subtype of EBF3-related neurodevelopmental disorders and other autism spectrum disorders.

Many people dread experiencing the cognitive and mood declines that often accompany reaching an advanced age, including memory disorders such as Alzheimer’s...

In this exciting study, Drs. Yamamotoand Wangler discover a new insight about autism spectrum disorders that it may not be one disorder involving many genes., but may actually be hundreds of genetic disorders.

In this exciting study, the Zoghbi lab find the cause and how to improve poor memory recall in Rett mice.

Chao lab study an unusual clinical case of NMIHBA case provides insights into this rare disease.

Bellen lab finds a new neurological disorder.

Reliably predicting whether meningioma, the most common primary brain tumor, will recur or remain benign has not been easy. In this study, published in Science Advances, researchers at Baylor College of Medicine and the Jan and Dan Duncan Neurological Research Institute (Duncan NRI) at Texas Children’s Hospital led by Dr. Akash Patel, continued their efforts to improve tumor prognostication.

The Yamamoto lab finds a novel role for TM2D gene family in Alzheimer's disease.

The discovery of TCF20 complex offers novel insights into the mechanisms of MECP2 disorders.

The study from the Bellen lab and published in the journal Science Advances, is the first to identify the underlying mechanism and possible drug targets for this new disorder.